An In Vivo Whole-Transcriptomic Approach to Assess Developmental and Reproductive Impairments Caused by Flumequine in Daphnia magna.

ABSTRACT: Among veterinary antibiotics, flumequine (FLU) is still widely used in aquaculture due to its efficacy and cost-effectiveness. Although it was synthesized more than 50 years ago, a complete toxicological framework of possible side effects on non-target species is still far from being achieved. The aim of this research was to investigate the FLU molecular mechanisms in Daphnia magna, a planktonic crustacean recognized as a model species for ecotoxicological studies. Two different FLU concentrations (2.0 mg L^-1 and 0.2 mg L^-1) were assayed in general accordance with OECD Guideline 211, with some proper adaptations. Exposure to FLU (2.0 mg L^-1) caused alteration of phenotypic traits, with a significant reduction in survival rate, body growth, and reprod

SUBMITTER: Pietropoli E 

PROVIDER: S-EPMC10253896 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature