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Crystal Structure of Staphopain C from Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus is a common opportunistic pathogen of humans and livestock that causes a wide variety of infections. The success of S. aureus as a pathogen depends on the production of an array of virulence factors including cysteine proteases (staphopains)-major secreted proteases of certain strains of the bacterium. Here, we report the three-dimensional structure of staphopain C (ScpA2) of S. aureus, which shows the typical papain-like fold and uncovers a detailed molecular description of the active site. Because the protein is involved in the pathogenesis of a chicken disease, our work provides the foundation for inhibitor design and potential antimicrobial strategies against this pathogen.

SUBMITTER: Magoch M

PROVIDER: S-EPMC10254297 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Crystal Structure of Staphopain C from Staphylococcus aureus.

Magoch Malgorzata M McEwen Alastair G AG Napolitano Valeria V Władyka Benedykt B Dubin Grzegorz G

Molecules (Basel, Switzerland) 20230529 11

Staphylococcus aureus is a common opportunistic pathogen of humans and livestock that causes a wide variety of infections. The success of S. aureus as a pathogen depends on the production of an array of virulence factors including cysteine proteases (staphopains)-major secreted proteases of certain strains of the bacterium. Here, we report the three-dimensional structure of staphopain C (ScpA2) of S. aureus, which shows the typical papain-like fold and uncovers a detailed mo ...[more]

PMID: 37298883

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