Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status.

ABSTRACT: Tau is a protein characterized by large structural portions displaying extended conformational changes. Unfortunately, the accumulation of this protein into toxic aggregates in neuronal cells leads to a number of severe pathologies, collectively named tauopathies. In the last decade, significant research advancements were achieved, including a better understanding of Tau structures and their implication in different tauopathies. Interestingly, Tau is characterized by a high structural variability depending on the type of disease, the crystallization conditions, and the formation of pathologic aggregates obtained from in vitro versus ex vivo samples. In this review, we reported an up-to-date and comprehensive overview of Tau structures reported in the Protein Data Bank, with a special focus

SUBMITTER: Pinzi L 

PROVIDER: S-EPMC10254443 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature