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Hydroxide-Mediated S_NAr Rearrangement for Synthesis of Novel Depside Derivatives Containing Diaryl Ether Skeleton as Antitumor Agents.

ABSTRACT: A simple and efficient hydroxide-mediated S_NAr rearrangement was reported to synthesize new depside derivatives containing the diaryl ether skeleton from the natural product barbatic acid. The prepared compounds were determined using ¹H NMR, ¹³C NMR, HRMS, and X-ray crystallographic analysis and were also screened in vitro for cytotoxicity against three cancer cell lines and one normal cell line. The evaluation results showed that compound 3b possessed the best antiproliferative activity against liver cancer HepG2 cell line and low toxicity, which made it worth further study.

SUBMITTER: Yu X

PROVIDER: S-EPMC10254537 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Hydroxide-Mediated SNAr Rearrangement for Synthesis of Novel Depside Derivatives Containing Diaryl Ether Skeleton as Antitumor Agents.

Yu Xiang X Xi Yinkai Y Sui Yi Y Liu Yang Y Chen Guifen G Zhang Minjie M Zhang Yan Y Luo Guoyong G Long Yi Y Yang Wude W

Molecules (Basel, Switzerland) 20230524 11

A simple and efficient hydroxide-mediated SNAr rearrangement was reported to synthesize new depside derivatives containing the diaryl ether skeleton from the natural product barbatic acid. The prepared compounds were determined using 1H NMR, 13C NMR, HRMS, and X-ray crystallographic analysis and were also screened in vitro for cytotoxicity against three cancer cell lines and one normal cell line. The evaluation results showed that compound 3b possessed the ...[more]

PMID: 37298778

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