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Palladium-Catalyzed N-Alkenylation of N-Aryl Phosphoramidates with Alkenes.

ABSTRACT: Versatile and concise Pd-catalyzed oxidative N-alkenylation of N-aryl phosphoramidates with alkenes is described in this study, a reaction that is of great significance but surprisingly unexploited. The transformation proceeds under mild reaction conditions, using O₂ as a green oxidant and TBAB as an effective additive. An efficient catalytic system allows a variety of drug-related substrates to participate in these transformations, which is of great interest in the drug discovery and development of phosphoramidates.

SUBMITTER: Li YA

PROVIDER: S-EPMC10254562 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Palladium-Catalyzed N-Alkenylation of N-Aryl Phosphoramidates with Alkenes.

Li Yu-An YA Wu Ge G Li Jia J

Molecules (Basel, Switzerland) 20230531 11

Versatile and concise Pd-catalyzed oxidative N-alkenylation of N-aryl phosphoramidates with alkenes is described in this study, a reaction that is of great significance but surprisingly unexploited. The transformation proceeds under mild reaction conditions, using O2 as a green oxidant and TBAB as an effective additive. An efficient catalytic system allows a variety of drug-related substrates to participate in these transformations, which is of great interest in the drug ...[more]

PMID: 37298944

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