Genetic Influence of Fracture Nonunion (FNU): A Systematic Review.

ABSTRACT:

Purpose

Nonunion of fractures occurs in about 15% of all fractures causing repeated surgical interference and prolonged morbidity. We performed this systematic review to assess genes and polymorphisms influencing fractures' nonunion (FNU).

Methods

We searched between 2000 and July 2022 in PubMed, EMBASE, the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews, Genome Wide Association Studies (GWAS) Catalog, and the Science Citation Index, with the keywords nonunion of fractures, genetic influence, and GWAS. The exclusion criteria were review articles and correspondence. The data were retrieved to determine the number of studies, genes, and polymorphisms and the total number of subjects screened.

Results

A total of 79 studies were

SUBMITTER: Sadat-Ali M 

PROVIDER: S-EPMC10254683 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature