Dataset Information

Assessing physical inactivity as a risk factor for chronic kidney diseases in Iranian population.

ABSTRACT:

Objectives

Physical inactivity is a major adjustable lifestyle risk factor in renal patients; nevertheless, research on the association of physical activity (PA) with chronic kidney disease (CKD) is unclear.

Design

Cross-sectional.

Setting

We evaluated the secondary care related to the nephrology specialists.

Participants

We evaluated PA in 3374 Iranian patients with CKD aged ≥18 years. Exclusion criteria were current or prior kidney transplantation, dementia, institutionalisation, expected to start renal replacement therapy or leave the area within study duration, participation in a clinical trial or inability to undergo the informed consent process.

Primary and secondary outcome

The renal function parameters were measured and compared with PA, assessed by the Baecke questionnaire. Estimated glomerular filtration rate, haematuria and/or albuminuria were used to estimate decreased kidney function and the incidence of CKD. To estimate the relationship between PA and CKD, we used the multinomial adjusted regression models.

Results

In the first model, findings indicate that the patients with the lowest PA score had significantly higher odds of CKD (OR 1.44, 95% CI 1.16 to 1.78; p=0.01), adjustment for age and sex attenuated this relationship (OR 1.25, 95% CI 1.56 to 1.78, p=0.04). Furthermore, adjusting for low-density lipoprotein, high-density lipoprotein, triglyceride, fasting blood glucose, body mass index, waist circumference, waist/hip ratio, coexisting diseases and smoking made this relationship insignificant (OR 1.23, 95% CI 0.97 to 1.55; p=0.076). After adjusting for potential confounders, we found that patients with lower PA have higher odds of CKD stage 2 (OR 1.62, 95% CI 1.13 to 2.32; p=0.008), no association with other CKD stages.

Conclusion

These data suggest that physical inactivity contributes to the risk of early CKD, so encouraging patients with CKD to maintain higher PA levels could be used as a simple and useful tool to decrease the risk of disease progression and its related burden.

SUBMITTER: Moeinzadeh F

PROVIDER: S-EPMC10254705 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Publications

Assessing physical inactivity as a risk factor for chronic kidney diseases in Iranian population.

Moeinzadeh Firouzeh F Babahajiani Media M Seirafian Shiva S Mansourian Marjan M Mortazavi Mojgan M Shahidi Shahrzad S Vahdat Sahar S Saleki Mohammad M

BMJ open 20230607 6

<h4>Objectives</h4>Physical inactivity is a major adjustable lifestyle risk factor in renal patients; nevertheless, research on the association of physical activity (PA) with chronic kidney disease (CKD) is unclear.<h4>Design</h4>Cross-sectional.<h4>Setting</h4>We evaluated the secondary care related to the nephrology specialists.<h4>Participants</h4>We evaluated PA in 3374 Iranian patients with CKD aged ≥18 years. Exclusion criteria were current or prior kidney transplantation, dementia, instit ...[more]

PMID: 37286321

Similar Datasets

Project description:BackgroundThe study aimed to investigate whether the associations of accelerometer-measured physical activity (PA) and sedentary behaviour (SB) with incident chronic kidney disease (CKD) vary based on different levels of hand grip strength, identifying the modifying role of grip strength in these associations.MethodsThe study included 87 487 adults from the UK Biobank. PA and SB were quantified using accelerometers over 7-day period, while grip strength was assessed using a hand dynamometer. CKD events were ascertained through hospital records or death registries.ResultsParticipants had a mean age of 62.3 years, with 57.2% (50 062) identifying as female and 97% as White. Over a median follow-up of 7.0 years, the total incidence rate of CKD was 4.7 per 1000 person-years. Participants who performed higher volumes of PA were more likely to be younger; have better control of body weight, blood glucose and blood pressure; and have fewer major comorbidities (p < 0.001). Total PA, moderate-to-vigorous intensity PA (MVPA), and light intensity PA (LPA), were inversely associated with CKD risk in a dose-response manner (all poverall < 0.050). In contrast, SB was associated with a higher risk of CKD (poverall < 0.001). Hand grip strength significantly modified the relationship between PA, SB, and CKD risk (pinteraction < 0.10). The associations of total PA (HR, 0.70; 95% CI, 0.59-0.84), MVPA (HR, 0.75; 95% CI, 0.65-0.88), LPA (HR, 0.81; 95% CI, 0.69-0.94), and SB (HR, 1.43; 95% CI, 1.21-1.69) with CKD risk were more remarkable among individuals with lower hand grip strength. Of note, physical inactivity ranked higher in relative strength for predicting CKD than hypertension, diabetes, and obesity.ConclusionsHand grip strength could significantly modify the associations of accelerometer-measured PA and SB with the risk of CKD. Regardless of intensity, PA consistently correlates with reduced risk of CKD, while SB is associated with increased risk, especially among individuals with lower grip strength. Notably, physical inactivity was found to be as predictive of CKD as traditional risk factors, highlighting the importance of promoting PA, especially among those with lower grip strength.

Dataset Information

Assessing physical inactivity as a risk factor for chronic kidney diseases in Iranian population.

Objectives

Design

Setting

Participants

Primary and secondary outcome

Results

Conclusion

Publications

Assessing physical inactivity as a risk factor for chronic kidney diseases in Iranian population.

Similar Datasets

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