Clinical features of Cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome and efficacy of the current therapy.

ABSTRACT:

Background

Cytomegalovirus retinitis (CMVR) is the most common and sight-threatening opportunistic retinal infection in patients with acquired immunodeficiency syndrome (AIDS) and several controversies remain to be settled. We aimed to summarize the current evidence and clarify the clinical features and prognosis of CMVR in AIDS patients.

Methods

The databases PubMed, EMBASE, and Ovid from inception to April 2022 were searched to identify the relevant studies. R software version 3.6.3 was used to perform the statistical analyses. Results in proportion with 95% confidence interval (CI) were calculated using the Freeman-Tukey variant of arcsine square transformation.

Results

We finally included 236 studies comprising 20,214 patients. CMVR in AIDS was male-dominated (88%

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC10254806 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature