Factors that influence the administration of tranexamic acid (TXA) to trauma patients in prehospital settings: a systematic review.

ABSTRACT:

Objective

In the UK there are around 5400 deaths annually from injury. Tranexamic acid (TXA) prevents bleeding and has been shown to reduce trauma mortality. However, only 5% of UK major trauma patients who are at risk of haemorrhage receive prehospital TXA. This review aims to examine the evidence regarding factors influencing the prehospital administration of TXA to trauma patients.

Design

Systematic literature review.

Data sources

AMED, CENTRAL, CINAHL, Cochrane Database of Systematic Reviews, Conference Proceedings Citation Index-Science, Embase and MEDLINE were searched from January 2010 to 2020; searches were updated in June 2022.

Clinicaltrials

gov and OpenGrey were also searched and forward and backwards citation chasing performed.

Eligibility criter

SUBMITTER: Nicholson H 

PROVIDER: S-EPMC10255319 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature