A Red-Light-Responsive DASA-Polymer with High Water Stability for Controlled Release.

ABSTRACT: Photoresponsive polymers hold vast potential in the realm of drug delivery. Currently, most photoresponsive polymers use ultraviolet (UV) light as the excitation source. However, the limited penetration ability of UV light within biological tissues serves as a significant hindrance to their practical applications. Given the strong penetration ability of red light in biological tissues, the design and preparation of a novel red-light-responsive polymer with high water stability, incorporating the reversible photoswitching compound and donor-acceptor Stenhouse adducts (DASA) for controlled drug release is demonstrated. In aqueous solutions, this polymer exhibits self-assembly into micellar nanovectors (~33 nm hydrodynamic diameter), facilitating the encapsulation of the hydrophobic model dru

SUBMITTER: Ma H 

PROVIDER: S-EPMC10255345 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature