Size Matters? A Comprehensive In Vitro Study of the Impact of Particle Size on the Toxicity of ZnO.

ABSTRACT: This study describes a comparative in vitro study of the toxicity behavior of zinc oxide (ZnO) nanoparticles and micro-sized particles. The study aimed to understand the impact of particle size on ZnO toxicity by characterizing the particles in different media, including cell culture media, human plasma, and protein solutions (bovine serum albumin and fibrinogen). The particles and their interactions with proteins were characterized in the study using a variety of methods, including atomic force microscopy (AFM), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Hemolytic activity, coagulation time, and cell viability assays were used to assess ZnO toxicity. The results highlight the complex interactions between ZnO NPs and biological systems, including their aggr

SUBMITTER: Mitjans M 

PROVIDER: S-EPMC10255545 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature