Biocompatible Polymer-Grafted TiO₂ Nanoparticle Sonosensitizers Prepared Using Phosphonic Acid-Functionalized RAFT Agent.

ABSTRACT: Sonodynamic therapy is widely used in clinical studies including cancer therapy. The development of sonosensitizers is important for enhancing the generation of reactive oxygen species (ROS) under sonication. Herein, we have developed poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-modified TiO₂ nanoparticles as new biocompatible sonosensitizers with high colloidal stability under physiological conditions. To fabricate biocompatible sonosensitizers, a grafting-to approach was adopted with phosphonic-acid-functionalized PMPC, which was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) using a newly designed water-soluble RAFT agent possessing a phosphonic acid group. The phosphonic acid group

SUBMITTER: Kitayama Y 

PROVIDER: S-EPMC10255893 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature