Blood flow modeling reveals improved collateral artery performance during the regenerative period in mammalian hearts.

ABSTRACT: Collateral arteries bridge opposing artery branches, forming a natural bypass that can deliver blood flow downstream of an occlusion. Inducing coronary collateral arteries could treat cardiac ischemia, but more knowledge on their developmental mechanisms and functional capabilities is required. Here we used whole-organ imaging and three-dimensional computational fluid dynamics modeling to define spatial architecture and predict blood flow through collaterals in neonate and adult mouse hearts. Neonate collaterals were more numerous, larger in diameter and more effective at restoring blood flow. Decreased blood flow restoration in adults arose because during postnatal growth coronary arteries expanded by adding branches rather than increasing diameters, altering pressure distributions. In hu

SUBMITTER: Anbazhakan S 

PROVIDER: S-EPMC10256232 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature