Divide and conquer: broadly neutralizing antibody combinations for improved HIV-1 viral coverage.

ABSTRACT:

Purpose of review

Successful HIV-1 prevention and therapy will require broad and potent coverage of within-host and global viral diversity. Broadly neutralizing antibody (bNAb) combination and multispecific therapeutics provide an opportunity to meet this challenge due to the complementary activity of individual antibody components. Here, we review the principles and applications of this concept.

Recent findings

The Antibody Mediated Prevention (AMP) trials have demonstrated the high bar for neutralization potency and breadth that bNAb-mediated prevention modalities will need to achieve to have a meaningful impact on the HIV-1 epidemic. Additional clinical studies have recently shown that an even higher bar may be required for therapeutic inhibition of the diverse within-hos

SUBMITTER: Wagh K 

PROVIDER: S-EPMC10256304 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature