Impact of vitamin D receptor polymorphisms in selected metabolic disorders.

ABSTRACT:

Purpose of review

Vitamin D (vitD) can regulate metabolic pathways in adipose tissue and pancreatic β cells by interacting with its vitamin D receptor (VDR). The aim of this study was to review original publications published in the last months and verify the relationship between genetic variants in the VDR gene and type 2 diabetes (T2D), metabolic syndrome (MetS), overweight, and obesity.

Recent findings

The recent studies concern genetic variants located in the coding and noncoding regions of the VDR gene. Some of the described genetic variants may affect VDR expression or posttranslational processing altered functionality or vitD binding capacity of VDR. Nevertheless, the data collected in recent months on the assessment of the relationship between VDR genetic variants an

SUBMITTER: Fronczek M 

PROVIDER: S-EPMC10256311 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature