Influence of genetic polymorphisms on serum biomarkers of cardiac health.

ABSTRACT: Cardiovascular diseases (CVDs) are a leading cause of death worldwide which is why early risk prediction is crucial. Discrete Polygenic risk score (PRS) measurement using saliva or dried blood spot samples collected at home poses a convenient means for early CVD risk assessment. The present study assessed the effects of 28 disease-associated single nucleotide polymorphisms (SNPs) on 16 serological cardiac markers and also aggregated the risk alleles into a PRS to evaluate its applicability in CVD-risk prediction. The study assessed genetic and serological markers in 184 individuals. The association between serological markers and individual genetic variants was evaluated using a two-tailed t test while the associations of serum markers with the PRS was analyzed using the Pearson correlatio

SUBMITTER: Krishnamurthy HK 

PROVIDER: S-EPMC10256409 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature