Prognostic and clinicopathological significance of TRIM21 in various cancers: A meta and bioinformatic analysis.

ABSTRACT:

Background

Tripartite motif-containing protein 21 (TRIM21), a member of the ubiquitin ligase family, makes a significant contribution to the ubiquitination of multiple tumor marker proteins associated with tumor cell proliferation, metastasis and selective apoptosis. As the research further develops, an increasing number of studies have manifested that the TRIM21 expression level can be considered an indicator of cancer prognosis. However, the interrelationship between TRIM21 and multiple forms of carcinogens has not been demonstrated in a meta-analysis.

Methods

We performed a systematic literature retrieval in various electronic databases including PubMed, Embase, Web of Science, Wanfang and China National Knowledge Infrastructure. Besides, the hazard ratio (HR) and the poo

SUBMITTER: Hu F 

PROVIDER: S-EPMC10256428 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature