Immunoglobulin directly enhances differentiation of oligodendrocyte-precursor cells and remyelination.

ABSTRACT: Multiple sclerosis (MS) is an inflammatory demyelinating disease characterized by multiple lesions in the central nervous system. Although the role of B cells in MS pathogenesis has attracted much attention, but the detailed mechanisms remain unclear. To investigate the effects of B cells on demyelination, we analyzed a cuprizone-induced demyelination model, and found that demyelination was significantly exacerbated in B cell-deficient mice. We next investigated whether immunoglobulin affected the myelin formation process using organotypic brain slice cultures and revealed that remyelination was improved in immunoglobulin-treated groups compared with the control group. Analysis of oligodendrocyte-precursor cell (OPC) monocultures showed that immunoglobulins directly affected on OPCs and pr

SUBMITTER: Li Y 

PROVIDER: S-EPMC10256778 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature