Colectomy in patients with ulcerative colitis is not associated to future diagnosis of primary sclerosing cholangitis.

ABSTRACT:

Background

Primary Sclerosing Cholangitis (PSC) is a hepatobiliary disease closely related to ulcerative colitis (UC). In PSC patients, colectomy has been linked to improved prognosis, especially following liver transplantation. This suggests an involvement of the gut-liver axis in PSC etiology.

Objective

We aimed to investigate the association between colectomy and the risk of future PSC in an epidemiological setting.

Method

Through nationwide registers, we identified all adults diagnosed with UC in Sweden 1990-2018 and retrieved information on PSC diagnosis and colectomy. Within the UC cohort (n = 61,993 patients), we matched 5577 patients with colectomy to 15,078 without colectomy. Matching criteria were sex, age at UC onset (±5 years), year of UC onset (±3 years),

SUBMITTER: Lundberg Bave A 

PROVIDER: S-EPMC10256996 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature