Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts.

ABSTRACT: Previous studies have hypothesized that autozygosity is decreasing over generational time. However, these studies were limited to relatively small samples (n < 11,000) lacking in diversity, which may limit the generalizability of their findings. We present data that partially support this hypothesis from three large cohorts of diverse ancestries, two from the US (All of Us, n = 82,474; the Million Veteran Program, n = 622,497) and one from the UK (UK Biobank, n = 380,899). Our results from a mixed-effect meta-analysis demonstrate an overall trend of decreasing autozygosity over generational time (meta-analyzed slope = -0.029, SE = 0.009, p = 6.03e-4). On the basis of our estimates, we would predict F_ROH to decline 0.29% for every 20-year increase in birth year. We determined tha

SUBMITTER: Colbert SMC 

PROVIDER: S-EPMC10257001 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature