Structural and functional analysis of the cerato-platanin-like protein Cpl1 suggests diverging functions in smut fungi.

ABSTRACT: Plant-pathogenic fungi are causative agents of the majority of plant diseases and can lead to severe crop loss in infected populations. Fungal colonization is achieved by combining different strategies, such as avoiding and counteracting the plant immune system and manipulating the host metabolome. Of major importance are virulence factors secreted by fungi, which fulfil diverse functions to support the infection process. Most of these proteins are highly specialized, with structural and biochemical information often absent. Here, we present the atomic structures of the cerato-platanin-like protein Cpl1 from Ustilago maydis and its homologue Uvi2 from Ustilago hordei. Both proteins adopt a double-Ψβ-barrel architecture reminiscent of cerato-platanin proteins, a class so far not described i

SUBMITTER: Weiland P 

PROVIDER: S-EPMC10257043 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature