Risk of Rabies and Implications for Postexposure Prophylaxis Administration in the US.

ABSTRACT:

Importance

In the US, rabies postexposure prophylaxis (PEP) is often administered without a comprehensive and regionally appropriate rabies risk assessment. For low-risk exposures, this can result in patients incurring out-of-pocket expenses or experiencing adverse effects of PEP unnecessarily.

Objective

To use a model to estimate (1) the probability that an animal would test positive for rabies virus (RABV) given that a person was exposed, and (2) the probability that a person would die from rabies given that they were exposed to a suspect rabid animal and did not receive PEP, and to propose a risk threshold for recommending PEP according to model estimates and a survey.

Design, setting, and participants

In this decision analytical modeling study, positivity rates we

SUBMITTER: Charniga K 

PROVIDER: S-EPMC10257100 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature