Associations between the Gut Microbiota, Urinary Metabolites, and Diet in Women during the Third Trimester of Pregnancy.

ABSTRACT:

Background

Pregnancy causes many metabolic and physiologic changes. However, associations between gut microbiota, dietary intake, and urinary metabolites are poorly characterized in pregnant women.

Objectives

The research objective was to identify dietary and microbial associations with urinary metabolites during pregnancy to elucidate potential biomarkers and microbial targets to improve maternal-fetal health. This is a secondary outcome of the study.

Methods

Pregnant women (n = 27) in the Pregnancy EAting and POstpartum Diapers pilot study provided dietary intake information in addition to fecal and urine samples at 36 wk gestation. The gut microbiota was characterized following fecal DNA extraction and 16S rRNA gene sequencing. Urinary metabolites were ident

SUBMITTER: Haddad EN 

PROVIDER: S-EPMC10257213 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature