Molecular profiling and prognostic biomarkers in chinese non-small cell lung cancer cohort.

ABSTRACT:

Introduction

Comprehensive information about the genome analysis and its prognostic values of NSCLC patients in Chinese population are still needed.

Patients

A total of 117 Chinese patients with NSCLC were enrolled in this study. Tumor tissues or blood were collected and sequenced by targeted next-generation sequencing of 556 cancer related genes. The associations between clinical outcomes and clinical characteristics, TMB, mutated genes, treatment therapies were analyzed using Kaplan-Meier methods and further evaluated using multivariable Cox proportional hazards regression model.

Results

A total of 899 mutations were identified by targeted NGS. The most frequently mutations included EGFR (47%), TP53 (46%), KRAS (18%), LRP1B (12%) and SPTA1 (10%). Patients with mutan

SUBMITTER: Shen F 

PROVIDER: S-EPMC10257305 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature