Abnormal HDL lipid and protein composition following pediatric cancer treatment: an associative study.

ABSTRACT:

Background

Long-term childhood cancer survivors (CCS) are at high risk of having dyslipidemia including low high density lipoprotein cholesterol (HDL-C). However, little is known about the prevalence of low HDL-C and the impact of therapy exposure on HDL composition early after treatment is terminated.

Methods

This associative study included 50 children and adolescents who had completed their cancer treatments (< 4 years). Clinical characteristics (demographic, diagnosis, treatment, anthropometric parameters), fasting plasma lipids, apoliporoteins (Apo) A-I and composition of HDL fractions (HDL2 and HDL3) were assessed. Data were stratified according to the presence of dyslipidemia and median doses of therapeutic agents and compared using Fisher exact or Mann-Whitney tests.

SUBMITTER: Belanger V 

PROVIDER: S-EPMC10257312 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature