HPV-positive murine oral squamous cell carcinoma: development and characterization of a new mouse tumor model for immunological studies.

ABSTRACT:

Background

Infection with high-risk human papillomavirus (HPV) strains is one of the risk factors for the development of oral squamous cell carcinoma (OSCC). Some patients with HPV-positive OSCC have a better prognosis and respond better to various treatment modalities, including radiotherapy or immunotherapy. However, since HPV can only infect human cells, there are only a few immunocompetent mouse models available that enable immunological studies. Therefore, the aim of our study was to develop a transplantable immunocompetent mouse model of HPV-positive OSCC and characterize it in vitro and in vivo.

Methods

Two monoclonal HPV-positive OSCC mouse cell lines were established by inducing the expression of HPV-16 oncogenes E6 and E7 in the MOC1 OSCC cell line using retroviral

SUBMITTER: Modic Z 

PROVIDER: S-EPMC10257320 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature