A miRNome analysis at the early postmortem interval.

ABSTRACT: The postmortem interval (PMI) is the time elapsing since the death of an individual until the body is examined. Different molecules have been analyzed to better estimate the PMI with variable results. The miRNAs draw attention in the forensic field to estimate the PMI as they can better support degradation. In the present work, we analyzed the miRNome at early PMI in rats' skeletal muscle using the Affymetrix GeneChip™ miRNA 4.0 microarrays. We found 156 dysregulated miRNAs in rats' skeletal muscle at 24 h of PMI, out of which 84 were downregulated, and 72 upregulated. The miRNA most significantly downregulated was miR-139-5p (FC = -160, p = 9.97 × 10^-11), while the most upregulated was rno-miR-92b-5p (FC = 241.18, p = 2.39 × 10^-6). Regarding the targets

SUBMITTER: Guardado-Estrada M 

PROVIDER: S-EPMC10257396 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature