Nanosecond pulsed electric field ablation-induced modulation of sphingolipid metabolism is associated with Ly6c2⁺ mononuclear phagocyte differentiation in liver cancer.

ABSTRACT: Preclinical studies have proven that nanosecond pulsed electric field (nsPEF) ablation can be a safe and effective treatment for humans with unresectable liver cancer that are ineligible for thermal ablation. The concomitant activation of antitumor immunity by nsPEF can also potentially prevent tumor recurrence. However, whether nsPEF exhibits similar efficacy in a clinical setting remains to be investigated. A prospective clinical trial (clinicaltrials.gov identifier: NCT04039747) was conducted to evaluate the safety and efficacy of ultrasound (US)-guided nsPEF ablation in 15 patients with unresectable liver cancer that were ineligible for thermal ablation. We found that nsPEF ablation was safe and produced a 12-month recurrence-free survival (RFS) and local RFS of 60% (9/15) and 86.7% (1

SUBMITTER: Liu J 

PROVIDER: S-EPMC10257421 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature