Revealing proteome-level functional redundancy in the human gut microbiome using ultra-deep metaproteomics.

ABSTRACT: Functional redundancy is a key ecosystem property representing the fact that different taxa contribute to an ecosystem in similar ways through the expression of redundant functions. The redundancy of potential functions (or genome-level functional redundancy [Formula: see text]) of human microbiomes has been recently quantified using metagenomics data. Yet, the redundancy of expressed functions in the human microbiome has never been quantitatively explored. Here, we present an approach to quantify the proteome-level functional redundancy [Formula: see text] in the human gut microbiome using metaproteomics. Ultra-deep metaproteomics reveals high proteome-level functional redundancy and high nestedness in the human gut proteomic content networks (i.e., the bipartite graphs connecting taxa to

SUBMITTER: Li L 

PROVIDER: S-EPMC10257714 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature