Bronchial epithelial cell transcriptional responses to inhaled corticosteroids dictate severe asthmatic outcomes.

ABSTRACT:

Background

Inhaled corticosteroids (CSs) are the backbone of asthma treatment, improving quality of life, exacerbation rates, and mortality. Although effective for most, a subset of patients with asthma experience CS-resistant disease despite receiving high-dose medication.

Objective

We sought to investigate the transcriptomic response of bronchial epithelial cells (BECs) to inhaled CSs.

Methods

Independent component analysis was performed on datasets, detailing the transcriptional response of BECs to CS treatment. The expression of these CS-response components was examined in 2 patient cohorts and investigated in relation to clinical parameters. Supervised learning was used to predict BEC CS responses using peripheral blood gene expression.

Results

We identifi

SUBMITTER: Ginebaugh SP 

PROVIDER: S-EPMC10257752 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature