Ontology highlight
ABSTRACT:
SUBMITTER: Sullivan DK
PROVIDER: S-EPMC10257951 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Sullivan Delaney K DK Deutzmann Anja A Yarbrough Josiah J Krishnan Maya S MS Gouw Arvin M AM Bellovin David I DI Adam Stacey J SJ Liefwalker Daniel F DF Dhanasekaran Renumathy R Felsher Dean W DW
Oncogene 20221007 45
MYC is a transcription factor frequently overexpressed in cancer. To determine how MYC drives the neoplastic phenotype, we performed transcriptomic analysis using a panel of MYC-driven autochthonous transgenic mouse models. We found that MYC elicited gene expression changes mostly in a tissue- and lineage-specific manner across B-cell lymphoma, T-cell acute lymphoblastic lymphoma, hepatocellular carcinoma, renal cell carcinoma, and lung adenocarcinoma. However, despite these gene expression chan ...[more]