Systems genetics identifies miRNA-mediated regulation of host response in COVID-19.

ABSTRACT:

Background

Individuals infected with SARS-CoV-2 vary greatly in their disease severity, ranging from asymptomatic infection to severe disease. The regulation of gene expression is an important mechanism in the host immune response and can modulate the outcome of the disease. miRNAs play important roles in post-transcriptional regulation with consequences on downstream molecular and cellular host immune response processes. The nature and magnitude of miRNA perturbations associated with blood phenotypes and intensive care unit (ICU) admission in COVID-19 are poorly understood.

Results

We combined multi-omics profiling-genotyping, miRNA and RNA expression, measured at the time of hospital admission soon after the onset of COVID-19 symptoms-with phenotypes from electronic health

SUBMITTER: Gjorgjieva T 

PROVIDER: S-EPMC10257974 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature