Cadmium-induced impairment of spermatozoa development by reducing exosomal-MVBs secretion: a novel pathway.

ABSTRACT: Cadmium is a heavy environmental pollutant that presents a high risk to male-fertility and targets the different cellular and steroidogenic supporting germ cells networks during spermatogenesis. However, the mechanism accounting for its toxicity in multivesicular bodies (MVBs) biogenesis, and exosomal secretion associated with spermatozoa remains obscure. In the current study, the light and electron microscopy revealed that, the Sertoli cells perform a dynamic role with secretion of well-developed early endosomes (Ee) and MVBs pathway associated with spermatozoa during spermatogenesis. In addition, some apical blebs containing nano-scale exosomes located on the cell surface and after fragmentation nano-scale exosomes were directly linked with spermatozoa in the luminal compartment of semin

SUBMITTER: Ali W 

PROVIDER: S-EPMC10258001 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature