[Genotype-environment interaction on arterial stiffness: A pedigree-based study].

ABSTRACT:

Objective

To utilized the baseline data of the Beijing Fangshan Family Cohort Study, and to estimate whether the association between a healthy lifestyle and arterial stiffness might be modified by genetic effects.

Methods

Probands and their relatives from 9 rural areas in Fangshan district, Beijing were included in this study. We developed a healthy lifestyle score based on five lifestyle behaviors: smoking, alcohol consumption, body mass index (BMI), dietary pattern, and physical activity. The measurements of arterial stiffness were brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI). A variance component model was used to determine the heritability of arterial stiffness. Genotype-environment interaction effects were performed by the maximum likelihood

SUBMITTER: Wang XH 

PROVIDER: S-EPMC10258065 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature