Comparison of endotracheal aspirate and bronchoalveolar lavage fluid metagenomic next-generation sequencing in severe pneumonia: a nested, matched case-control study.

ABSTRACT:

Objectives

To compare clinical outcomes in patients with severe pneumonia according to the diagnostic strategy used.

Methods

In this retrospective, nested, case-control study, patients with severe pneumonia who had undergone endotracheal aspirate (ETA) metagenomic next-generation sequencing of (mNGS) testing (n = 53) were matched at a ratio of 1 to 2 (n = 106) by sex, age, underlying diseases, immune status, disease severity scores, and type of pneumonia with patients who had undergone bronchoalveolar lavage fluid (BALF) mNGS. The microbiological characteristics and patient's prognosis of the two groups were compared.

Results

An overall comparison between the two groups showed no significant differences in bacterial, fungal, viral, or mixed infections. However, subgro

SUBMITTER: Bao R 

PROVIDER: S-EPMC10258078 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature