The effect of COVID-19 vaccination on anticoagulation stability in adolescents and young adults using vitamin K antagonists.

ABSTRACT:

Introduction

The European Medicine Agency has authorized COVID-19 vaccination in adolescents and young adults (AYAs) from 12 years onwards. In elderly vitamin K antagonist (VKA) users, COVID-19 vaccination has been associated with an increased risk of supra- and subtherapeutic INRs. Whether this association is also observed in AYAs using VKA is unknown. Our aim was to describe the stability of anticoagulation after COVID-19 vaccination in AYA VKA users.

Materials and methods

A case-crossover study was performed in a cohort of AYAs (12-30 years) using VKAs. The most recent INR results before vaccination, the reference period, were compared with the most recent INR after the first and, if applicable, second vaccination. Several sensitivity analyses were performed in which we r

SUBMITTER: Visser C 

PROVIDER: S-EPMC10258126 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature