Computer-assisted drug repurposing for thymidylate kinase drug target in monkeypox virus.

ABSTRACT:

Introduction

Monkeypox is a zoonotic disease caused by brick-shaped enveloped monkeypox (Mpox) virus that belongs to the family of ancient viruses known as Poxviridae. Subsequently, the viruses have been reported in various countries. The virus is transmitted by respiratory droplets, skin lesions, and infected body fluids. The infected patients experience fluid-filled blisters, maculopapular rash, myalgia, and fever. Due to the lack of effective drugs or vaccines, there is a need to identify the most potent and effective drugs to reduce the spread of monkeypox. The current study aimed to use computational methods to quickly identify potentially effective drugs against the Mpox virus.

Methods

In our study, the Mpox protein thymidylate kinase (A48R) was targeted because it is

SUBMITTER: Ajmal A 

PROVIDER: S-EPMC10258308 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature