Gut microbiota and type 1 diabetes: a two-sample bidirectional Mendelian randomization study.

ABSTRACT:

Objective

The real causal relationship between human gut microbiota and T1D remains unclear and difficult to establish. Herein, we adopted a two-sample bidirectional mendelian randomization (MR) study to evaluate the causality between gut microbiota and T1D.

Methods

We leveraged publicly available genome-wide association study (GWAS) summary data to perform MR analysis. The gut microbiota-related GWAS data from 18,340 individuals from the international consortium MiBioGen were used. The summary statistic data for T1D (n = 264,137) were obtained from the latest release from the FinnGen consortium as the outcome of interest. The selection of instrumental variables conformed strictly to a series of preset inclusion and exclusion criteria. MR-Egger, weighted median, inverse vari

SUBMITTER: Luo M 

PROVIDER: S-EPMC10258312 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature