Failure to decrease HbA1c levels following TB treatment is associated with elevated Th1/Th17 CD4+ responses.

ABSTRACT:

Introduction

The rising global burden of metabolic disease impacts the control of endemic tuberculosis (TB) in many regions, as persons with diabetes mellitus (DM) are up to three times more likely to develop active TB than those without DM. Active TB can also promote glucose intolerance during both acute infection and over a longer term, potentially driven by aspects of the immune response. Identifying patients likely to have persistent hyperglycemia following TB treatment would enable closer monitoring and care, and an improved understanding of underlying immunometabolic dysregulation.

Methods

We measured the relationship of plasma cytokine levels, T cell phenotypes and functional responses with the change in hemoglobin A1c (HbA1c) before and after treatment of pulmonary T

SUBMITTER: Krause R 

PROVIDER: S-EPMC10258338 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature