Development and validation of an endoplasmic reticulum stress-related molecular prognostic model for breast cancer.

ABSTRACT:

Background

Breast cancer is the most frequently diagnosed cancer and a leading cause of cancer-related death in women. Endoplasmic reticulum stress (ERS) plays a crucial role in the pathogenesis of several malignancies. However, the prognostic value of ERS-related genes in breast cancer has not been thoroughly investigated.

Methods

We downloaded and analyzed expression profiling data for breast invasive carcinoma samples in The Cancer Genome Atlas-Breast Invasive Carcinoma (TCGA-BRCA) and identified 23 ERS-related genes differentially expressed between the normal breast tissue and primary breast tumor tissues. We constructed and validated risk models using external test datasets. We assessed the differences in sensitivity to common antitumor drugs between high- and low-scori

SUBMITTER: Fan P 

PROVIDER: S-EPMC10258344 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature