Changing Smoking Behavior and Epigenetics: A Longitudinal Study of 4,432 Individuals From the General Population.

ABSTRACT:

Background

Hypomethylation of the aryl hydrocarbon receptor repressor (AHRR) gene indicates long-term smoking exposure and might therefore be a monitor for smoking-induced disease risk. However, studies of individual longitudinal changes in AHRR methylation are sparse.

Research question

How does the recovery of AHRR methylation depend on change in smoking behaviors and demographic variables?

Study design and methods

This study included 4,432 individuals from the Copenhagen City Heart Study, with baseline and follow-up blood samples and smoking information collected approximately 10 years apart. AHRR methylation at the cg05575921 site was measured in bisulfite-treated leukocyte DNA. Four smoking groups were defined: participants who never smoked (Never-Never), particip

SUBMITTER: Skov-Jeppesen SM 

PROVIDER: S-EPMC10258440 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature