RNA Editing Enzyme ADAR1 Suppresses the Mobility of Cancer Cells via ARPIN.

ABSTRACT: Deamination of adenine or cytosine in RNA, called RNA editing, is a constitutively active and common modification. The primary role of RNA editing is tagging RNA right after its synthesis so that the endogenous RNA is recognized as self and distinguished from exogenous RNA, such as viral RNA. In addition to this primary function, the direct or indirect effects on gene expression can be utilized in cancer where a high level of RNA editing activity persists. This report identified actin-related protein 2/3 complex inhibitor (ARPIN) as a target of ADAR1 in breast cancer cells. Our comparative RNA sequencing analysis in MCF7 cells revealed that the expression of ARPIN was decreased upon ADAR1 depletion with altered editing on its 3'UTR. However, the expression changes of ARPIN were not depende

SUBMITTER: Park MJ 

PROVIDER: S-EPMC10258462 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature