Proteomic characterization of acute kidney injury in patients hospitalized with SARS-CoV2 infection.

ABSTRACT:

Background

Acute kidney injury (AKI) is a known complication of COVID-19 and is associated with an increased risk of in-hospital mortality. Unbiased proteomics using biological specimens can lead to improved risk stratification and discover pathophysiological mechanisms.

Methods

Using measurements of ~4000 plasma proteins in two cohorts of patients hospitalized with COVID-19, we discovered and validated markers of COVID-associated AKI (stage 2 or 3) and long-term kidney dysfunction. In the discovery cohort (N = 437), we identified 413 higher plasma abundances of protein targets and 30 lower plasma abundances of protein targets associated with COVID-AKI (adjusted p < 0.05). Of these, 62 proteins were validated in an external cohort (p < 0.05, N = 261).

Results

We demon

SUBMITTER: Paranjpe I 

PROVIDER: S-EPMC10258469 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature