RNA N⁶-methyladenosine profiling reveals differentially methylated genes associated with intramuscular fat metabolism during breast muscle development in chicken.

ABSTRACT: Intramuscular fat (IMF) is an important indicator for determining meat quality, and IMF deposition during muscle development is regulated by a complex molecular network involving multiple genes. The N⁶-methyladenosine (m⁶A) modification of mRNA plays an important regulatory role in muscle adipogenesis. However, the distribution of m⁶A and its role in IMF metabolism in poultry has not been reported. In the present study, a transcriptome-wide m⁶A profile was constructed using methylated RNA immunoprecipitation sequence (MeRIP-seq) and RNA sequence (RNA-seq) to explore the potential mechanism of regulating IMF deposition in the breast muscle based on the comparative analysis of IMF differences in the breast muscles of 42 (group G), 126 (group S), an

SUBMITTER: Yu B 

PROVIDER: S-EPMC10258505 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature