COVID-19-associated pulmonary aspergillosis in immunocompetent patients: a virtual patient cohort study.

ABSTRACT: The opportunistic fungus Aspergillus fumigatus infects the lungs of immunocompromised hosts, including patients undergoing chemotherapy or organ transplantation. More recently however, immunocompetent patients with severe SARS-CoV2 have been reported to be affected by COVID-19 Associated Pulmonary Aspergillosis (CAPA), in the absence of the conventional risk factors for invasive aspergillosis. This paper explores the hypothesis that contributing causes are the destruction of the lung epithelium permitting colonization by opportunistic pathogens. At the same time, the exhaustion of the immune system, characterized by cytokine storms, apoptosis, and depletion of leukocytes may hinder the response to A. fumigatus infection. The combination of these factors may explain the onset of invasive as

SUBMITTER: Ribeiro HAL 

PROVIDER: S-EPMC10258510 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature