Gene transcriptional expression of cortical thinning during childhood and adolescence.

ABSTRACT: The cognitive and behavioral development of children and adolescents is closely related to the maturation of brain morphology. Although the trajectory of brain development has been depicted in detail, the underlying biological mechanism of normal cortical morphological development in childhood and adolescence remains unclear. By combining the Allen Human Brain Atlas dataset with two single-site magnetic resonance imaging data including 427 and 733 subjects from China and the United States, respectively, we performed partial least squares regression and enrichment analysis to explore the relationship between the gene transcriptional expression and the development of cortical thickness in childhood and adolescence. We found that the spatial model of normal cortical thinning during childhood

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC10258537 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature