Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.

ABSTRACT: Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic hallmarks of Alzheimer's disease^1,2. The regional progression of brain atrophy in Alzheimer's disease highly correlates with tau accumulation but not amyloid deposition^3-5, and the mechanisms of tau-mediated neurodegeneration remain elusive. Innate immune responses represent a common pathway for the initiation and progression of some neurodegenerative diseases. So far, little is known about the extent or role of the adaptive immune response and its interaction with the innate immune response in the presence of amyloid-β or tau pathology⁶. Here we systematically compared the i

SUBMITTER: Chen X 

PROVIDER: S-EPMC10258627 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature