Environmental tobacco smoke exposure and non-syndromic orofacial cleft: Systematic review and meta-analysis.

ABSTRACT:

Introduction

Environmental tobacco smoke (ETS) is associated with several congenital anomalies, including non-syndromic orofacial clefts (NSOFCs). This systematic review aimed to update the literature on the association between ETS and NSOFCs.

Methods

Four databases were searched up to March 2022, and studies that evaluated the association between ETS and NSOFCs were selected. Two authors selected the studies, extracted the data, and evaluated the risk of bias. Comparing the association of maternal exposure to ETS and active parental smoking with NSOFCs allowed for the creation of pooled effect estimates for the included studies.

Results

Twenty-six studies were deemed eligible for this review, of which 14 were reported in a previous systematic review. Twenty five were

SUBMITTER: Sabbagh HJ 

PROVIDER: S-EPMC10258680 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature