Dataset Information

Multiple lineages of monkeypox virus detected in the United States, 2021-2022.

ABSTRACT: Monkeypox is a viral zoonotic disease endemic in Central and West Africa. In May 2022, dozens of non-endemic countries reported hundreds of monkeypox cases, most with no epidemiological link to Africa. We identified two lineages of monkeypox virus (MPXV) among two 2021 and seven 2022 US monkeypox cases: the major 2022 outbreak variant called B.1 and a minor contemporaneously sampled variant called A.2. Analyses of mutations among these two variants revealed an extreme preference for GA-to-AA mutations indicative of human APOBEC3 cytosine deaminase activity among Clade IIb MPXV (previously West African, Nigeria) sampled since 2017. Such mutations were not enriched within other MPXV clades. These findings suggest that APOBEC3 editing may be a recurrent and a dominant driver of MPXV evolution within the current outbreak.

SUBMITTER: Gigante CM

PROVIDER: S-EPMC10258808 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Multiple lineages of monkeypox virus detected in the United States, 2021-2022.

Gigante Crystal M CM Korber Bette B Seabolt Matthew H MH Wilkins Kimberly K Davidson Whitni W Rao Agam K AK Zhao Hui H Smith Todd G TG Hughes Christine M CM Minhaj Faisal F Waltenburg Michelle A MA Theiler James J Smole Sandra S Gallagher Glen R GR Blythe David D Myers Robert R Schulte Joann J Stringer Joey J Lee Philip P Mendoza Rafael M RM Griffin-Thomas LaToya A LA Crain Jenny J Murray Jade J Atkinson Annette A Gonzalez Anthony H AH Nash June J Batra Dhwani D Damon Inger I McQuiston Jennifer J Hutson Christina L CL McCollum Andrea M AM Li Yu Y

Science (New York, N.Y.) 20221020 6619

Monkeypox is a viral zoonotic disease endemic in Central and West Africa. In May 2022, dozens of non-endemic countries reported hundreds of monkeypox cases, most with no epidemiological link to Africa. We identified two lineages of monkeypox virus (MPXV) among two 2021 and seven 2022 US monkeypox cases: the major 2022 outbreak variant called B.1 and a minor contemporaneously sampled variant called A.2. Analyses of mutations among these two variants revealed an extreme preference for GA-to-AA mut ...[more]

PMID: 36264825

Similar Datasets

Project description:Leishmaniasis is a rare disease in the United States, with an estimated annual incidence of dozens of cases occurring primarily in travelers, migrants, and military personnel. True disease incidence is unknown, since leishmaniasis is not a nationally notifiable condition. Here, we describe the results of molecular leishmaniasis over a 1-year interval (September 2021 to August 2022) when our laboratory served as the primary national reference laboratory for molecular diagnosis of civilian leishmaniasis. We tested 218 specimens submitted from 36 states yielding 94 of the 186 (50.5%) positive cases with species or species complex-level identification and 18 novel mini-exon alleles. Most species belonged to subgenus Viannia (75.6%) and associated with cutaneous or mucocutaneous disease. Cases were associated with recent travel (18.1%), travel timing unspecified (7.4%), migration (7.4%), remote travel (2.1%), military (1.1%), or unknown history (63.8%). These data illustrate the clinical utility of molecular testing for leishmaniasis and provide unique insight into disease epidemiology.ImportanceLeishmaniasis is a disfiguring, neglected parasitic infection endemic to the Southern United States and the Americas. Despite significant populations at risk-travelers, military and foreign service members, and migrating persons-the epidemiology of the disease in the United States is poorly understood. Moreover, few clinical laboratories in the United States can test for the disease. Here, we present results from 1 year of testing for this disease at a major reference laboratory. These findings are particularly relevant because they coincide with a temporary "pause" on all clinical testing at the CDC. Our findings suggest at least several hundred cases occur each year in the United States. In particular, mucosal leishmaniasis may be more common than previously reported. We also highlight greater genetic diversity in Leishmania species endemic to the Americas than has been previously sampled, with implications for diagnostic specificity.

Dataset Information

Multiple lineages of monkeypox virus detected in the United States, 2021-2022.

Publications

Multiple lineages of monkeypox virus detected in the United States, 2021-2022.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets