Simple and Efficient Synthesis of Diamino Derivatives of bis-1,2,4-oxadiazole via Tandem Staudinger/aza-Wittig Reaction.

ABSTRACT: Two efficient, scalable routes to bis-1,2,4-oxadiazole have been developed by tandem Staudinger/aza-Wittig reaction from the same starting material diaziglyoxime, isocyanates and triphenylphosphonium in good yields.

Background

Two convenient and efficient routes for synthesizing diamino derivatives of bis-1,2,4- oxadiazoles were described.

Objective

This study provides a simple protocol for the synthesis of bis-1,2,4-oxadiazoles.

Methods

The two procedures were based on a tandem Staudinger/aza-Wittig reaction from the same starting material of diaziglyoxime, isocyanates and triphenylphosphonium.

Results

In synthesis method I, diaziglyoxime 1 was treated with various aromatic or aliphatic isocyanates to give diazioxalimides 2 a high yield. Diazioxalimides 2 react

SUBMITTER: Xie H 

PROVIDER: S-EPMC10258914 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature